ATP Science Acetyl L-Carnitinefrom $29.95
Acetyl L-Carnitine benefits the brain and body A large body of scientific evidence points to the positive effects of dietary supplementation of Acetyl L-Carnitine (Acetyl L-Carnitine). Acetyl L-Carnitine is the principal acetyl ester of L-Carnitine (LC), and it plays an essential role in intermediary metabolism, acting as a donor of acetyl groups and facilitating the transfer of fatty acids from cytosol to mitochondria during beta-oxidation. This means it will help you burn fat. Dietary supplementation of Acetyl L-Carnitine exerts neuroprotective, neurotrophic, anti-depressive and analgesic effects in painful conditions. Acetyl L-Carnitine also has antioxidant and anti-apoptotic activity. Moreover, Acetyl L-Carnitine exhibits positive effects on mitochondrial metabolism, and shows promise in the treatment of aging and neurodegenerative pathologies by slowing the progression of mental deterioration.1 Fat burning Fat exhibits a relatively low maximal rate of oxidation in vivo, which begins to decline at around 65% of VO2max when muscle glycogen becomes the major fuel. It is thought that if the rate of fat oxidation during endurance exercise could be augmented, then muscle glycogen depletion could be delayed and endurance improved. “Such an amazing product! Smoothest Carnitine! I dry scoop and the ATP brand is by far the easiest to swallow dry. – @Lizemslie Mitochondrial carnitine palmitoyltransferase 1 (CPT1) is thought to be the rate-limiting step in skeletal muscle fat oxidation, but there are several other potential control points that could influence the decline in the rate of fat oxidation during intense endurance exercise including: (1) regulation of lipolysis within adipose tissue; (2) delivery of free fatty acids from adipose tissue to skeletal muscle; (3) transport of fatty acids across the muscle cell membrane and within the cell cytosol; and (4) intramitochondrial enzymatic reactions distal to CPT1.2 Consuming Acetyl L-Carnitine upregulates the rate limiting fat burning step meaning that you can burn more fat when you exercise. Boosting dopamine in the brain Dopamine in the brain is a good thing for focus and drive when you are training. Boosting the brain’s dopamine before hitting the gym is a goal of lots of pre-workout powders. The great thing is that Acetyl L-Carnitineachieves this goal3, while also have the wonderful ‘side effect’ of promoting fat burning. Dopamine is a hormone that governs much of our brain activity. Dopamine is associated with many neurological functions: cognition, learning, attention, memory, desire, pleasure, punishment, reward, motivation, sleep, mood, behaviour, and voluntary movement. It is no wonder that Acetyl L-Carnitine is a ‘must take’ supplement for the serious trainer. Studies on the benefits of Carnitine In mammals, during the aging process, an atrophy of the muscle fibres, an increase in body fat mass, and a decrease in skeletal muscle oxidative capacities occur. Compounds and activities that interact with lipid oxidative metabolism may be useful in limiting damages that occur in aging muscle. In one study, they evaluated the effect of L-carnitine and physical exercise on several parameters related to muscle physiology. They supplemented old rats with L-carnitine for 12 weeks (a) allowed the restoration of L-carnitine level in muscle cells, (b) restored muscle oxidative activity in the muscles, and (c) induced positive changes in body composition: a decrease in abdominal fat mass and an increase in muscle capabilities without any change in food intake.4 Why should I take the ATP Science Acetyl L-Carnitine? ATP Science Acetyl L-Carnitines benefits include: Allergen, pesticide, heavy metal and microbial tested for compliance Approved material manufacturer that will allow audits of their factory HPLC verified guaranteeing fully efficacious material and no contaminants or adulteration Vegan friendly Gluten free GMO free Sugar free Front Biosci (Landmark Ed). 2016 Jun 1;21:1314-29. The neurobiology of acetyl-L-carnitine. Traina G. Nestle Nutr Inst Workshop Ser. 2013;76:13-23. Carnitine and fat oxidation. Stephens FB1, Galloway SD. J Neurosci Res. 1991 Nov;30(3):555-9. Effect of acetyl-L-carnitine on the dopaminergic system in aging brain. Sershen H1, Harsing LG Jr, Banay-Schwartz M, Hashim A, Ramacci MT, Lajtha A. J Gerontol A Biol Sci Med Sci. 2008 Oct;63(10):1027-33. L-carnitine supplementation and physical exercise restore age-associated decline in some mitochondrial functions in the rat. Bernard A1, Rigault C, Mazue F, Le Borgne F, Demarquoy J. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease
EHP Labs Acetyl L-Carnitine$34.95
EHPlabs Acetyl L-Carnitine is HPLC tested and proven to be the highest quality pharmaceutical grade Acetyl L-Carnitine on the market. The fine crystalline powder and the potency of a concentrated serving size is testament to this. Acetyl L-Carnitine is a naturally occurring amino acid that promotes the transportation of free fatty acids into the mitochondria (core of the cells), where they are burned off as energy. Acetyl L-Carnitine also assists muscle recovery after strenuous exercise and promotes optimal heart and brain function. EHPlabs wanted to ensure that the Acetyl L-Carnitine pharmaceutical quality was maintained, hence, this product has not been artificially flavored or colored. Acetyl L-Carnitine has a naturally occurring sour lemon taste and EHPLabs recommends that it should be taken as a "stack" product, and mixed into a serving of OxyShred, BUZZ or Beyond BCAA. DIRECTIONS Mix 1-2 scoops with 10 Ounces (295 ml) of water, juice or beverage of your choice. Do not exceed 5 scoops per day. Acetyl L-Carnitine is 100% stack-safe and can ideally be added to OxyShred to maximize metabolic activity and fat loss. ASIDE FROM TRANSPORTING FREE FATTY ACIDS, WHAT ELSE DOES ACETYL L-CARNITINE DO? Acetyl L-Carnitine is well known for producing energy, improving brain performance, decreasing stress and depression, and slowing the effects of ageing related diseases including dementia. WHAT SHOULD I FEEL WHEN I CONSUME ACETYL L-CARNITINE? EHPlabs Acetyl L-Carnitine is pharmaceutical grade and contains no additional stimulants. You will not feel any major high stim effects, however, Acetyl L-Carnitine will work alongside your natural biological processes to utilize fat cells to increase energy (ATP) production and will lead to increased sweating during training. This indicates that your metabolism is speeding up and youre burning more calories during your training. WHAT DOES IT TASTE LIKE? Acetyl L-Carnitine has a slightly tart/sour taste, but it is subtle enough that you will barely notice the taste when you add it to OxyShred, BUZZ or Beyond BCAA.
Gen-Tec Nutrition Acetyl L-Carnitine$49.95
100% ACETYL L-CARNITINE POWDER BASIC FUNCTIONS Fat metabolism, cognitive functions (ie reflexs and co-ordination), vigilance, fatloss, mind/muscle connection. Acetyl L-Carnitine (ALC) plays a critical role in not only lipid and energy metabolism but also within nerve cells of the central nervous system (CNS) (Rebouche, 2012). Research shows that in the periphery skeletal muscle sites, ALC is a co-factor for beta-oxidation (metabolism of fatty acids)whereby it mops up available fats to be sent to the muscle cells for metabolism (Stephens et al., 2007, Kido et al., 2001). More specifically it translocates long chain fatty acids (LCFA) to the mitochondrial matrix where it can undergo beta oxidation and enter the Kreb cycle for fat derived ATP re-synthesis (Stephens et al., 2007). This involvement in fat metabolism is also one way by which ALC assists with energy levels during exercise. It is important to understand that the mitochondria is an organelle within a cell that functions to produce energy by ATP synthesis from primarily fats and carbohydrates (Stephens et al., 2007). If the mitochondria is a factory to burn fuel then ALC is the employee who transports that fuel into the factory to be burned. If there is insufficient ALC (employees) then naturally there is a reduced mitochondrial (factory) use of fats (fuel). In addition, ALC can reduce the amount of muscle damage experienced by intense exercise by acting as mitochondrial antioxidant, which if revisiting the previous factory analogy, within every factory there must be some level of maintenance to ensure the longevity and proper functioning of machinery, so ALC is like that oil or maintenance check to ensure a healthy and functioning environment for fats (fuel) to be burned (Stephens et al., 2007). Moreover, ALC crosses the blood brain barrier which means it exhibits activity in not only the muscle cells for energy but also in the brain and nerve cells (Kido et al., 2001). Over recent years research has revealed that ALC acts as a neuro-protective agent against alcohol related nerve cell damage and glucose transportation to the brain (Abdul Muneer et al., 2011). Furthermore, evidence has indicated possible clinical benefit for ALC use in neurodegenerative conditions such as Alzheimers disease, diabetic neuropathy and other conditions resulting in nerve damage (Malaguarnera, 2012, Ruggenenti et al., 2009). It appears that ALC assists with the activity of cholinergic neurons, membrane stabilization and mitochondrial function (Palacios et al., 2011). To further understand how, we must understand that the brain and nerve cells also require adequate energy supply, so they too poses mitochondria within the nerve cells (Palacios et al., 2011). The difference between muscle cell mitochondria mentioned above and neuronal cell mitochondria is that neuronal mitochondria are more vulnerable to oxidative stress (wear and tear by producing energy), therefore a strong mitochondrial antioxidant like ALC can provide ongoing maintenance checks to all nerve cells (Palacios et al., 2011, Rebouche, 2012). In addition to ALC s use for increased metabolism of fats in the mitochondria and its neuro-protective properties in a range of clinical settings, it is also shown to assist with reproductive function and glucose tolerance (Showell et al., 1996). Studies which have explored ALCs use in patients with low sperm count concluded that although ALC does not conclusively increase the quantity of sperm, it does improve sperm motility and quality (Busetto et al., 2012). In women who suffer from a neuroendocrine impairment, which adversely affects their reproductive axis, ALC is reported to significantly improve Luteinizing hormone (LH) profiles and stress induced abnormalities caused by the condition resulting in improved well-being and energy levels (Genazzani et al., 2011). Lastly in patients with abnormal glucose tolerance, ALC significantly improved insulin sensitivity and glucose functioning with the cessation of ALC resulting in immediate reversal of acquired benefits from ALC (Ruggenenti et al., 2010, Ruggenenti et al., 2009). Once patients went back on ALC their glucose tolerance improved again, thus demonstrating a multi-factorial benefit from ALC in the body. ABDUL MUNEER, P. M., ALIKUNJU, S., SZLACHETKA, A. M. & HAORAH, J. 2011. Inhibitory effects of alcohol on glucose transport across the blood-brain barrier leads to neurodegeneration: preventive role of acetyl-L: -carnitine. Psychopharmacology, 214, 707-18. BUSETTO, G. M., KOVERECH, A., MESSANO, M., ANTONINI, G., DE BERARDINIS, E. & GENTILE, V. 2012. Prospective open-label study on the efficacy and tolerability of a combination of nutritional supplements in primary infertile patients with idiopathic astenoteratozoospermia. Archivio Italiano di Urologia, Andrologia, 84, 137-40. GENAZZANI, A. D., LANZONI, C., RICCHIERI, F., SANTAGNI, S., RATTIGHIERI, E., CHIERCHIA, E., MONTELEONE, P. & JASONNI, V. M. 2011. Acetyl-L-carnitine (ALC) administration positively affects reproductive axis in hypogonadotropic women with functional hypothalamic amenorrhea. Journal of Endocrinological Investigation, 34, 287-91. KIDO, Y., TAMAI, I., OHNARI, A., SAI, Y., KAGAMI, T., NEZU, J.-I., NIKAIDO, H., HASHIMOTO, N., ASANO, M. & TSUJI, A. 2001. Functional relevance of carnitine transporter OCTN2 to brain distribution of l-carnitine and acetyl-l-carnitine across the bloodbrain barrier. Journal of Neurochemistry, 79, 959-969. MALAGUARNERA, M. 2012. Carnitine derivatives: clinical usefulness. Current Opinion in Gastroenterology, 28, 166-76. PALACIOS, H. H., YENDLURI, B. B., PARVATHANENI, K., SHADLINSKI, V. B., OBRENOVICH, M. E., LESZEK, J., GOKHMAN, D., GASIOROWSKI, K., BRAGIN, V. & ALIEV, G. 2011. Mitochondrion-specific antioxidants as drug treatments for Alzheimer disease. CNS & Neurological Disorders Drug Targets, 10, 149-62. REBOUCHE, C. J. 2012. L-Carnitine. Present Knowledge in Nutrition. Wiley-Blackwell. RUGGENENTI, P., CATTANEO, D., LORIGA, G., LEDDA, F., MOTTERLINI, N., GHERARDI, G., ORISIO, S. & REMUZZI, G. 2009. Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy. Hypertension, 54, 567-74. RUGGENENTI, P., VAN DER MEER, I. M. & REMUZZI, G. 2010. Oral acetyl-L-carnitine therapy and insulin resistance. Hypertension, 55, e26. SHOWELL, M. G., BROWN, J., YAZDANI, A., STANKIEWICZ, M. T. & HART, R. J. 1996. Antioxidants for male subfertility. Cochrane Database of Systematic Reviews. John Wiley & Sons, Ltd. STEPHENS, F. B., CONSTANTIN-TEODOSIU, D. & GREENHAFF, P. L. 2007. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. The Journal of Physiology, 581, 431-444. SUGGESTED USED For Fat Loss Use 1 level teaspoon (2 grams) 10-20 mins before cardio upon rising (use with 10ml Ultimate Thermo Fuel). For Athletic Performance ie weight lifters, boxers, bodybuilders etc) Use 1 level teaspoon (2 grams) 20 mins before training or event. TIPS For endurance athletes and to help reduce fatigue Use with 200mg Advance Nutrition Co-Enzyme Q10. For Fat Loss use with 10ml Ultimate Thermo Fuel.