L-Glutamine – real muscle food.

L-Glutamine is non-essential and conditionally essential in humans, meaning the body can usually synthesize sufficient amounts of it, but in some instances of stress (such as intense exercise), the body’s demand for glutamine increases and glutamine must be obtained from the diet. In fact, glutamine is so important to the body, it is the most abundant amino acid found in the blood.

L-Glutamine:

• Reduces muscle soreness after exercise (DOMS)
• Catabolic states, such as major trauma, sepsis, major surgery and bone marrow transplantation as well as intense chemotherapy and radiotherapy, are associated with low plasma levels of glutamine
• Reduced availability of glutamine in these conditions may lead to an impaired immune function because of a reduced capacity of immune cells to proliferate
• Glutamine is the respiratory fuel for the lymphocytes, hepatocytes and the mucosal cells of the gut
• Glutamine is one of the most important substrates for ammoniagenesis, not only in the gut, but also in the kidney, because of its important role in the regulation of acid-base homeostasis

The Science of L-Glutamine – reducing the DOMS!

A study examined the effects that L-glutamine supplementation has on quadriceps muscle strength and soreness ratings following resistance exercise. It was thought that glutamine ingestion would quicken the recovery rate of peak force production and decrease muscle soreness ratings over a 72-hr recovery period. Sixteen healthy participants volunteered in a double-blind, randomized, placebo-controlled crossover study. Muscle soreness was measured before, immediately following, 24, 48, and 72 hr post-resistance exercise. L-glutamine resulted in greater relative peak power during the exercise. In all the individuals, L-glutamine resulted in lower soreness ratings at 24, 48 and 72 hour post-exercise. The bottom line is that L-glutamine supplementation resulted in faster recovery of peak power and diminished muscle soreness following exercise.

“L- GLUTAMINE… a key factor to proper muscle recovery & repair ? An increase in L- glutamine supplementation this prep has worked wonders ?? I’m training harder than ever, but my body is recovering so much better ?

– Days with weight training: 5g in the morning, 5g intra workout & 5g before bed 

– Rest days/cardio only days: 5g in the morning & another 5g before bed.”

– @caseyfento

The impressive resume of L-Glutamine

A variety of investigations have provided evidence that glutamine has become an important and, possibly essential, amino acid during stressors such as intense exercise. This switch to becoming an essential amino acid appears when the demand of the body for glutamine increases markedly. The plasma glutamine use exceeds the glutamine synthesis of the skeletal muscle and the liver in catabolic conditions. Circulating glutamine is an important substrate for the enterocyte, hepatocyte and immune cells as an oxidative fuel as well as a substrate for nucleotide synthesis.

Muscle medicine

Clinical trials provide important confirmation that dietary glutamine supplementation is indeed associated with amelioration of metabolic response to stress and injury. Moreover, in selected critically ill patients, glutamine seems to improve their outcome. The mechanisms of these effects remain elusive and are the subject of ongoing investigations. Supplemental glutamine improves nitrogen balance and preserves the concentration of glutamine in skeletal muscle.

Fluid balance

In selected patients, glutamine preserves normal distribution of body water by preventing expansion of extracellular water and reducing fluid retention. This is vital for competition prep if you are a body builder or, if you simply want to look better.

Gut health

In the critically ill patient with breakdown of the intestinal barrier, exogenous glutamine may protect the host from gut-derived endotoxemic complications. A possible mechanism for the helpful effects of glutamine on the stressed gut is the increased production of arginine, which serves as a precursor for nitric oxide, a potent vasodilator.

Exercise induced gut leaking

Intestinal permeability and systemic inflammation are associated with gastrointestinal (GI) distress, in which paracellular endotoxin leakage triggers an immune response, causing disruption to intestinal epithelial cell absorption mechanisms. Exercise-induced hyperthermia in humans is associated with an increase in intestinal permeability, commonly called leaky gut, which provokes an inflammatory cascade. This pathway may be responsible for exercise-induced GI distress in which tight junction (TJ) breakdown and increased permeability is the initial phase of the pathway. The good news is that 7 days of oral glutamine supplementation protected the gut during high-intensity endurance exercise by reducing intestinal permeability. Keep in mind, this study induced gut leakage by exercising for a mere 60 minutes. That is an average workout length!

Why should I take the ATP Science L-Glutamine?

Benefits of ATP Science L-Glutamine are:

• Allergen, pesticide, heavy metal and microbial tested for compliance
• Approved material manufacturer that will allow audits of their factory
• HPLC verified guaranteeing fully efficacious material and no contaminants or adulteration
• Vegan
• Gluten free
• GMO free
• Sugar free

1. Lacey, JM; Wilmore, DW (Aug 1990). “Is glutamine a conditionally essential amino acid?”. Nutrition Reviews. 48 (8): 297–309.
2. Alteration of Plasma Glutamate and Glutamine Levels in Children with High-Functioning Autism Chie Shimmura, Shiro Suda , Kenji J. Tsuchiya, Kenji Hashimoto, Koji Ohno, Hideo Matsuzaki, Keiko Iwata, Kaori Matsumoto, Tomoyasu Wakuda, Yosuke Kameno, Katsuaki Suzuki, Masatsugu Tsujii, Kazuhiko Nakamura, Nori Takei, Norio Mori Published: October 5, 2011
3. Int J Sport Nutr Exerc Metab. 2015 Oct;25(5):417-26. The Influence of Oral L-Glutamine Supplementation on Muscle Strength Recovery and Soreness Following Unilateral Knee Extension Eccentric Exercise. Legault Z1, Bagnall N, Kimmerly DS.
4. Petra G. Boelens, Robert J. Nijveldt2, Alexander P. J. Houdijk2, Sybren Meijer, and Paul A. M. van Leeuwen3 J. Nutr. September 1, 2001 vol. 131 no. 9 2569S-2577S
5. Petra G. Boelens, Robert J. Nijveldt2, Alexander P. J. Houdijk2, Sybren Meijer, and Paul A. M. van Leeuwen3 J. Nutr. September 1, 2001 vol. 131 no. 9 2569S-2577S
6. Petra G. Boelens, Robert J. Nijveldt2, Alexander P. J. Houdijk2, Sybren Meijer, and Paul A. M. van Leeuwen3 J. Nutr. September 1, 2001 vol. 131 no. 9 2569S-2577S
7. J Appl Physiol (1985). 2014 Jan 15;116(2):183-91. Effects of oral glutamine supplementation on exercise-induced gastrointestinal permeability and tight junction protein expression. Zuhl MN1, Lanphere KR, Kravitz L, Mermier CM, Schneider S, Dokladny K, Moseley PL

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease

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