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No, HMB does not really stand for
"Helping Muscles Build" but rather it is an abbreviation of its long chemical
name, b-hydroxy b-methyl butyrate. However, one thing HMB does do is build muscle. HMB is
a natural substance and is produced in the body by all of us, young and old. In
actual fact, HMB is a second order derivative of the branch-chain amino acid L-leucine.
Put in more simple terms, HMB is produced when L-Leucine is metabolised or broken down in
the body, first into ketoisocaproic acid (KIC) and then into HMB. HMB is not a drug but
has been proven to be a potent, natural anti-catabolic agent; it stops muscle breakdown!
What can HMB do for me?
As an athlete, it is important to preserve as much of your
muscle as possible. Training, restricted diet, hormones and all sorts of factors can
produce a catabolic effect. This results in a loss of muscle. HMB is anti-catabolic - not
anabolic. An anti-catabolic agent prevents muscle breakdown, an anabolic agent stimulates
muscle growth. To build muscle, we train. When we train we have to take one step back to
go two steps forward. HMB takes out the backward step, effectively letting you go three
steps forward. How does HMB work?
No-one really knows exactly how HMB works. There
are many myths about how HMB works circulating around gyms and health food shops - HMB
increases testosterone is one of the most common myths. HMB is not known to have this
effect but as stated before, no-one knows exactly how HMB works! An Iowa State University
study showed that a dose of 1.5-3.0 grams daily significantly decreased exercise-induced
muscle breakdown and increased fat-free mass gain in subjects on a seven week weight
training program. Researchers also found that HMB-supplemented subjects lifted more weight
than unsupplemented subjects during all three weeks. Those subjects receiving HMB were
able to perform more abdominal exercises (unsupplemented subjects increased performance by
14%, and supplemented subjects increased performance by 50%). Additionally, total strength
(combining increases for upper- and lower-body exercises) increased 8% in unsupplemented
subjects, 13% in the 1.5-gram-HMB group, and 18.4% in the 3-gram-HMB group. Thirty-two
male volunteers (ages 19-22) participated in the second study. These men were divided into
two groups receiving either no HMB or three grams of HMB per day, and they lifted weights
for two to three hours per day, six days a week for seven weeks. The early measurements in
the study indicated that the subjects who received HMB developed significantly more
fat-free mass than those who lifted weights but didn't take HMB. Bench-press strength was
almost three times greater in the group receiving HMB, and strength increases for the
squat, although not
statistically significant, were also
greater. The results of these two studies
are particularly impressive since the evidence of HMB's effectiveness was found in both
biochemical tests (3-methylhistidine and creatine-kinase measurements designed to track
muscle protein breakdown) and in more practical measurements (subjects gained fat-free
mass and got stronger). These benefits occurred with HMB independent of the level of
protein intake in these subjects. However, it's important to note that the group consuming
the least amount of protein was still ingesting more than twice the RDA level suggested
for maintaining nitrogen balance. So it could be that a protein intake considered normal
by non-bodybuilding standards would limit the benefits of HMB
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